Publications

2025

• Inducing in operando chloride ion filtration through an electrocatalytic film architecture integrated with ZIF-8 nanosheets En route to seawater electrolysis
  
  • Harvey Catherine
  • Delacroix Simon
  • Marchat Clément
  • Gacoin Thierry
  • Tard Cédric
  Electrochimica Acta, Elsevier, 2025, 544, pp.147664. Ameliorating direct seawater electrolysis to produce green hydrogen requires an advancement in the conception of material designs and electrocatalytic film architectures. Indeed, to complement the hydrogen evolution reaction (HER) at the cathode, oxygen must be produced thanks to the oxygen evolution reaction (OER) at the anode. Nevertheless, this kinetically slow reaction is in competition with the kinetically facile chlorine evolution reaction (CER). In this work, the entropic selectivity of the ZIF-8 MOF molecular sieving material and the high aspect ratio of a nanosheet morphology was probed to induce the in situ selective filtration of the undesired chloride ion towards the electrocatalyst surface, namely iridium nanoparticles interdispersed on Vulcan carbon. Cross-sectional analysis revealed a homogeneous dispersion of the nanosheets within the electrocatalytic film. This composite catalyst enabled a ~65 % drop in CER selectivity upon increasing the Zn/Ir molar ratio when evaluated at a disk current density of 3 mA/cm 2 at a chloride ion concentration of 10 mM. Further evaluating the CER selectivity at lower current densities along the disk indicated a near 95 % drop in CER selectivity at 500 mM chloride ion concentration, shown through rotating ring disk electrode experiments. A competitive absorbing mechanism was indicated and the unchanged kinetics of the CER suggests a decrease of the CER current due to an induced diffusional control. The development of a composite architecture enabling the in operando filtration of chloride ions seems promising towards producing hydrogen by direct seawater electrolysis. (10.1016/j.electacta.2025.147664)
  DOI : 10.1016/j.electacta.2025.147664
• Nexus approach to enhance water-energy-food security and ecosystems resilience under climate change in the Mediterranean
  
  • Drobinski Philippe
  • Rivera Ferre Marta
  • Monem Mohamed Abdel
  • Hatab Assem Abu
  • Behnassi Mohamed
  • Chfadi Tarik
  • Cramer Wolfgang
  • Debolini Marta
  • Driouech Fatima
  • El-Kenawy Ahmed
  • García-Vila Margarita
  • Guiot Joël
  • Lamonaca Emilia
  • López-I-Gelats Feliu
  • Malek Žiga
  • Papadopoulou Maria
  • Santeramo Fabio
  npj Climate Action, Springer Nature, 2025, 4 (1), pp.115. The Mediterranean Basin, already a water-scarcity hotspot, faces intensifying droughts and warming that strain the water–energy–food–ecosystems (WEFE) nexus. Climate impacts cascade across sectors, while siloed responses risk maladaptation. Nexus-based solutions—centred on water—can foster synergies and reduce trade-offs, with nature-based, socially inclusive, and clean energy strategies offering transformative potential. Yet governance, cooperation, and data gaps persist; closing these is vital to operationalize the nexus and advance regional sustainability. (10.1038/s44168-025-00308-4)
  DOI : 10.1038/s44168-025-00308-4
• Myomerger-derived peptide enhances skeletal muscle tropism and reduces liver transduction of lipid nanoparticles for gene delivery
  
  • Ji Jacqueline
  • Lipkow Eva
  • Anton Nicolas
  • Crucifix Corinne
  • Eberling Pascal
  • Laporte Jocelyn
  Molecular Therapy - Nucleic Acids, Elsevier, 2025, 37 (1), pp.102785. Lipid nanoparticles (LNPs) are emerging as nonviral vectors for gene therapy; yet, their strong liver tropism and lack of tissue specificity remain limiting. Here, we developed, through rational design, a skeletal muscle-targeted delivery platform by functionalizing LNPs with MyomP1, an extracellular conserved peptide derived from the muscle-specific fusogenic protein Myomerger. MyomP1-LNPs were engineered to encapsulate plasmid DNA or mRNA. In vitro, MyomP1 conjugation significantly increased transduction efficiency in murine and human myoblasts and myotubes. In vivo, MyomP1-LNPs significantly enhanced muscle transduction when delivering DNA cargo, strongly reduced liver accumulation following intramuscular and intravenous mRNA delivery, and attenuated local immune activation. This work demonstrates a ligand-guided strategy to overcome organ-specific barriers in nonviral gene transfer, with improved safety and specificity. It suggests that MyomP1-engineered LNPs hold strong potential to improve therapeutic outcomes for patients with rare muscle diseases, offering a promising alternative to traditional viral gene therapy platforms. (10.1016/j.omtn.2025.102785)
  DOI : 10.1016/j.omtn.2025.102785
• Stress dependence of the chemical potential of lithium in a silicon electrode
  
  • Le Anh Tuan
  • Bruant Xavier
  • Phung Ngoc Tram
  • Ozanam Francois
  • Rosso Michel
  • Guin Laurent
  Journal of the Mechanics and Physics of Solids, Elsevier, 2025. We report operando measurements and concurrent modeling of the stress dependence of the chemical potential of lithium in a silicon electrode. An experimental study is carried out on hydrogenated amorphous silicon thin films in which the electrode stress state is modified operando during electrochemical lithiation and delithiation by applying an external mechanical load. During galvanostatic cycling, the electrode is periodically subjected to a tensile strain, inducing stress variations that are reflected in voltage changes. The measured stress-induced voltage changes are interpreted using a well-established chemomechanical model of lithium insertion in silicon. Comparison of voltage measurements with model predictions allows us to determine the concentration-dependent Young's modulus (from 29 GPa to 26 GPa with increasing lithium content) and some of the viscoplastic parameters of lithiated silicon. The calibrated model shows good predictive capability when applied to lithiation cycles performed at a C-rate different from that of the calibration cycle. However, it shows limitations in explaining voltage changes under delithiation. These results show that thermodynamically-consistent chemomechanical models of lithiation not only adequately describe the effect of lithium insertion and deinsertion on stress, as already shown in the literature, but also capture the reverse effect of stress on lithium insertion. In this respect, this work opens up new perspectives for the quantitative validation and calibration of existing diffusion-deformation theories, notably by highlighting their possible limitations. (10.1016/j.jmps.2025.106421)
  DOI : 10.1016/j.jmps.2025.106421
• Brown adipose tissue activity impacts systemic lactate clearance in male mice
  
  • Montané Rémi
  • Jeanson Yannick
  • Lagarde Damien
  • Khoury Spiro
  • Porcher-Bibes Léana
  • Nakhle Jean
  • Sallese Marie
  • Parny Mélissa
  • Raymond-Letron Isabelle
  • Huard Emma
  • de Souza Raphael Alves
  • Galinier Anne
  • Pellerin Luc
  • Sore Anne‐karine Bouzier
  • Pradère Jean‐philippe
  • Moro Cédric
  • Casteilla Louis
  • Yart Armelle
  • Dray Cédric
  • Portais Jean‐charles
  • Ader Isabelle
  • Carriere Audrey
  The Journal of Physiology, Wiley, 2025. Non-shivering thermogenesis in brown adipose tissue (BAT) is linked to metabolic health. Yet, how its activity states impact on systemic metabolism and in particular on lactate, a highly abundant metabolite increasingly recognized as a critical player in energy metabolism, remains unresolved. The goal of this study was to investigate the impact of BAT activity on lactate metabolism at the whole organism level. To activate or inactivate non-shivering thermogenesis in BAT, we housed C57Bl6/J male mice at 4, 21 and 30°C and then conducted lactate tolerance tests. In mice exposed to cold exposure (4°C), systemic lactate clearance was elevated. In contrast, clearance of systemic lactate was poor in mice housed under thermoneutral conditions (30°C) that inactivate BAT thermogenesis, as well as in mice deficient for the mitochondrial uncoupling protein-1. To better understand lactate metabolic fate during the clearance phase, in vivo stable isotope tracing experiments with labelled 13C-lactate and analyses by mass spectrometry were performed. These experiments revealed that lactate contribution to gluconeogenesis was increased under cold exposure while its contribution to the tricarboxylic acid cycle was reduced in BAT under thermoneutrality. Remarkably, we also identified that lactate entered a pyruvate cycling process that was highly active in BAT, and repressed at thermoneutrality. Our study shows that inactivation of non-shivering thermogenesis decreased systemic lactate clearance, concomitantly with changes in metabolic fate of lactate in BAT and in gluconeogenic organs, in male mice. (10.1113/JP288871)
  DOI : 10.1113/JP288871
• Distinguishing carriers' and lattice's temperatures through photoluminescence analysis
  
  • Vezin Thomas
  • Zhu Xiangyu
  • Salhani Chloe
  • Bescond Marc
  • Hirakawa Kazuhiko
  • Suchet Daniel
  Journal of Physics: Condensed Matter, IOP Publishing [1989-....], 2025. We report the direct and independent measurement of the lattice and the electrons temperatures in a nanocooler device (asymmetric double-barrier semiconductor heterostructure) at different operating points. Both temperatures are estimated from photoluminescence measurements -the former through the shift of the absorptivity profile, the latter through the shape of the blackbody baseline. The device's cooling feature results from the thermionic extraction of electrons injected in a quantum well through an energy selective barrier. While electrons exhibit a spectacular cooling for resonant injection, the lattice temperature remains essentially unaffected, with a temperature decrease at the resolution limit. Further from resonance, both systems show an identical thermal behavior governed by Joule's heating. The similarities and discrepancies of the temperature profiles illustrate the complex thermal behavior of the system, epitomize the need of reliable thermometry method and showcase the ability of photoluminescence to do so. (10.1088/1361-648X/ae1178)
  DOI : 10.1088/1361-648X/ae1178
• Achieving energy efficiency in microservice-based cloud applications: a systematic study
  
  • Perdigão Batista César
  • Barros Glauber
  • Batista Thais
  • Chabridon Sophie
  • Conan Denis
  , 2026, 16082, pp.405-424. The growth of Cloud computing has enabled scalable and accessible services, while also intensifying concerns over energy consumption, carbon emissions, and both the environmental and financial sustainability of data centers. Microservice architectures offer promising opportunities for granular resource optimization and energy savings, though it can also introduce complexities. It is crucial to investigate how microservice-based Cloud applications address energy efficiency. For this purpose, we conducted a systematic literature review (SLR) aiming to establish an overview of the state-of-the-art on energy-efficient microservice-based Cloud applications. The research questions of the SLR focus on revealing: (i) strategies to mitigate energy inefficiencies in microservice-based Cloud applications; (ii) experimental methodologies used to assess the effectiveness of the proposed strategy, and (iii) mechanisms for measuring energy consumption. As a result, 25 studies were selected and synthesized to provide a comprehensive overview about the topic. This paper also presents a taxonomy and raises important challenges and potential directions for future research. (10.1007/978-3-032-04200-2_28)
  DOI : 10.1007/978-3-032-04200-2_28
• Lot-sizing under decision-dependent uncertainty: A probing-enhanced stochastic programming approach
  
  • Quezada Franco
  • Gicquel Céline
  • Kedad-Sidhoum Safia
  • Pagnoncelli Bernardo
  , 2025. We address the multi-item capacitated lot-sizing problem under decision-dependent uncertainty via a probing-enhanced stochastic programming framework. Demand is correlated with another random vector, and the decision-maker can acquire partial information by probing components of this vector, conditioning decisions on observed covariates. This generalizes classical models by embedding information acquisition into a three-stage framework. We propose a compact reformulation that removes non-anticipativity constraints, yielding stronger relaxations and better tractability. We extend classical inequalities and introduce value-function cuts that capture the link between probing and recourse costs. These are embedded in a branch-and-cut algorithm with a primal heuristic. Results show our method outperforms off-the-shelf solver, reducing optimality gaps by up to 85%, and achieving gaps below 1.5% on average. Results highlight the importance of structured reformulation, valid inequalities, and heuristics in solving decision-dependent stochastic programs.
• Gold nanoparticles combined with ultrafine TiO 2 layer: a reliable probe for Raman thermometry
  
  • Khitous Amine
  • Molinaro Céline
  • Rumyantseva Anna
  • Kochtcheev Serguei
  • Adam Pierre-Michel
  • Bachelot Renaud
  • Soppera Olivier
  Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2025, 27 (38), pp.20817-20827. Temperature determination methods in metal nanoparticles are essential for providing information on energy dissipation dynamics in such systems and for temperature-sensitive applications, hence the need for high-performance thermometry techniques is evident. In this study, we propose new efficient probes for Raman antiStokes-Stokes thermometry based on gold nanoparticles (AuNPs), prepared by thermal dewetting and controllably functionalized with a 2 nm TiO2 layer by the sol–gel method. AuNPs@TiO2 demonstrated good stability and a usable response over a temperature range from 25 °C to 240 °C generated by external thermal and thermoplasmonic heating of the sample. We validate the methodology by taking into account the spectral efficiency of the Raman spectrometer as well as the extinction properties of AuNPs@TiO2 in the calculations. This approach enables us to propose a reliable temperature measurement over two hundred degrees range. (10.1039/D5CP02372F)
  DOI : 10.1039/D5CP02372F
• Towards calibration of picosecond O-TALIF
  
  • Shu Z
  • Latorre Sopie
  • Billeau J.B.
  • Booth Jean-Paul
  • Seletskiy D.V.
  • Reuter Stefan
  • Popov N.A.
  • Starikovskaia Svetlana
  , 2025. Experimental procedure of obtaining the Xe/O two-photon absorption cross-section ratio is discussed for nanosecond and picosecond TALIF experiments. The same nanosecond capillary discharge with 100% oxygen dissociation at 30 mbar pressure is used as a source of O-atoms.
• Parallel evolution of salinity tolerance in Arabidopsis thaliana accessions from Cape Verde Islands
  
  • Martínez Rivas Félix
  • Wozny Dorothee
  • Xue Zeyun
  • Gilbault Elodie
  • Sapir Thomas
  • Rouille Melissa
  • Ricou Antony
  • Medina Joaquín
  • Noël Laurent
  • Lauber Emmanuelle
  • Voxeur Aline
  • Mazier Marianne
  • Loudet Olivier
  • Clément Gilles
  • Jiménez-Gómez Jose
  Science Advances, American Association for the Advancement of Science (AAAS), 2025, 11 (28). Soil salinization poses a notable threat to agriculture. The Cape Verde Islands are located 600 km off the coast of Africa and are characterized by arid environments and high-salinity soils. Here, we find that Arabidopsis thaliana plants native to these islands accumulate glucuronyl-mannose that protects them from salt stress. We map the ability to produce this metabolite to an α glycosidase family 38 gene that we named GH38cv . Plants carrying mutant alleles of GH38cv do not present defects on growth, fitness, or biotic resistance under standard laboratory conditions but show better germination rates, longer roots, better hydric status, and higher fitness than nonmutated plants when exposed to salt stress. Notably, deleterious mutations in GH38cv have evolved independently on two separate islands within the Cape Verde archipelago, illustrating an example of parallel evolution for salt tolerance in this environment. Our findings reveal a knowledge-driven method to develop salt-resilient crops, which could be attractive to both conventional and organic agriculture. (10.1126/sciadv.adq8210)
  DOI : 10.1126/sciadv.adq8210
• Benzochalcogenodiazoles, Synthesis, and Applications in Medicinal Chemistry and Photomedicine
  
  • Zheng Jean‐elie
  • Franck Xavier
  • Gallavardin Thibault
  European Journal of Organic Chemistry, Wiley-VCH Verlag, 2025, 28 (23). Benzochalcogenodiazoles (BXDs) (BOD: benzoxadiazole, BTD: benzothiadiazole, or BSD: benzoselenadiazole) are aromatic bicyclic compounds, containing chalcogen atoms, with applications ranging from material to medicinal chemistry. The recent developments in their preparation and functionalization are taking advantage of new methodologies such as CH activation and photocatalysis. After being almost restricted to organic semiconductor materials for optoelectronics applications, they are gaining more and more interest in medicinal chemistry as lipophilic aromatic fragments. Their unique optical properties make them attractive in biological imaging and in photomedicine, with emission up to the near‐infrared biological transparency window. The nature of the chalcogen atom influences their optical properties, with sulfur and selenium atoms favoring phototherapy over fluorescence. This review will not describe optoelectronic materials and fluorophores based on BXD but will focus on the preparation of BXD‐containing compounds, and their medicinal and photomedicinal applications. (10.1002/ejoc.202500228)
  DOI : 10.1002/ejoc.202500228
• Combining dynamin 2 myopathy and neuropathy mutations rescues both phenotypes
  
  • Goret Marie
  • Edelweiss Evelina
  • Jehl Jérémy
  • Reiss David
  • Aguirre-Pineda Patricio
  • Friant Sylvie
  • Laporte Jocelyn
  Nature Communications, Nature Publishing Group, 2025, 16 (1), pp.4667. Mutations within a single gene can lead to diverse human genetic diseases affecting highly specialized tissues. Notably, dominant mutations in the DNM2 gene, encoding the mechanoenzyme dynamin, lead to distinct neuromuscular disorders: centronuclear myopathy (CNM) and Charcot-Marie-Tooth neuropathy (CMT). CNM is characterized by myofiber structural anomalies while CMT presents peripheral nerve defects, both culminating in muscle weakness and atrophy. Despite their shared genetic origin, the mechanisms driving these diseases remain elusive, and no cure is available. Here, we present in vitro assays underlining opposing effects of DNM2 mutations, gain-of-function in CNM and loss-of-function in CMT. In vivo, we explored the potential compensatory effects of CNM and CMT mutations by breeding Dnm2 S619L/+ CNM with Dnm2 K562E/+ CMT mouse models. Dnm2 S619L/K562E offspring exhibit strongly improved motor coordination and muscle strength and mass, compared to single-mutant littermates. Dnm2 S619L/K562E mice present normalized muscle structure and nerve fiber organization. This study reveals that two distinct disease-causing mutations within the DNM2 gene compensate each other in vivo, leading to corrections of most individual phenotypes. The inverse modulation of DNM2 activity emerges as a promising therapeutic strategy to address CNM and CMT diseases. (10.1038/s41467-025-59925-6)
  DOI : 10.1038/s41467-025-59925-6
• Coordination bonds as a tool for tuning photoconductance in nanostructured hybrid materials made of molecular antennas and metal nanoparticles
  
  • Marchenko Nataliia
  • Martin Deborah
  • Pham Adeline
  • Abid Seifallah
  • Cretal Eva
  • Ibarra Alfonso
  • Lagarde Delphine
  • Tassé Marine
  • Bonvoisin Jacques
  • Rapenne Gwénaël
  • Grisolia Jérémie
  • Kammerer Claire
  • Tricard Simon
  Materials Horizons, the Royal Society of Chemistry, 2025, 10 (12), pp.3429-3435. The synthesis of robust, versatile materials in which electrical conduction is enhanced by light irradiation is of prime importance for fields as varied as photodetectors, photodiodes, solar cells and light sensors. Hybrid materials offer the advantage of combining the robustness of an inorganic building block with the adaptability of a molecular subunit. Herein, we demonstrate the importance of properly investigating the nature of the chemical interactions between the constituent elements in order to optimize photoconductance within hybrid materials. To this end, platinum nanoparticle self-assemblies are synthesized in solution, including a series of zinc-porphyrins differentially functionalized with pyridine moieties in the meso position. The presence of coordinating groups on the molecular entities drastically reinforced both the structural cohesion of the system and its photoconductive properties. (10.1039/D4MH01327A)
  DOI : 10.1039/D4MH01327A